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Minoxidil may suppress androgen receptor-related functions

Overview of attention for article published in Oncotarget, April 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

Mentioned by

twitter
4 tweeters
patent
1 patent
reddit
1 Redditor
video
1 video uploader

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
40 Mendeley
Title
Minoxidil may suppress androgen receptor-related functions
Published in
Oncotarget, April 2014
DOI 10.18632/oncotarget.1886
Pubmed ID
Authors

Cheng-Lung Hsu, Jai-Shin Liu, An-Chi Lin, Chih-Hsun Yang, Wen-Hung Chung, Wen-Guey Wu

Abstract

Although minoxidil has been used for more than two decades to treat androgenetic alopecia (AGA), an androgen-androgen receptor (AR) pathway-dominant disease, its precise mechanism of action remains elusive. We hypothesized that minoxidil may influence the AR or its downstream signaling. These tests revealed that minoxidil suppressed AR-related functions, decreasing AR transcriptional activity in reporter assays, reducing expression of AR targets at the protein level, and suppressing AR-positive LNCaP cell growth. Dissecting the underlying mechanisms, we found that minoxidil interfered with AR-peptide, AR-coregulator, and AR N/C-terminal interactions, as well as AR protein stability. Furthermore, a crystallographic analysis using the AR ligand-binding domain (LBD) revealed direct binding of minoxidil to the AR in a minoxidil-AR-LBD co-crystal model, and surface plasmon resonance assays demonstrated that minoxidil directly bound the AR with a K(d) value of 2.6 µM. Minoxidil also suppressed AR-responsive reporter activity and decreased AR protein stability in human hair dermal papilla cells. The current findings provide evidence that minoxidil could be used to treat both cancer and age-related disease, and open a new avenue for applications of minoxidil in treating androgen-AR pathway-related diseases.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 40 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 15%
Researcher 6 15%
Student > Bachelor 6 15%
Student > Master 5 13%
Student > Doctoral Student 4 10%
Other 9 23%
Unknown 4 10%
Readers by discipline Count As %
Medicine and Dentistry 12 30%
Pharmacology, Toxicology and Pharmaceutical Science 9 23%
Agricultural and Biological Sciences 5 13%
Biochemistry, Genetics and Molecular Biology 3 8%
Economics, Econometrics and Finance 1 3%
Other 5 13%
Unknown 5 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 October 2021.
All research outputs
#3,752,110
of 19,040,944 outputs
Outputs from Oncotarget
#1,570
of 13,746 outputs
Outputs of similar age
#77,478
of 302,209 outputs
Outputs of similar age from Oncotarget
#105
of 858 outputs
Altmetric has tracked 19,040,944 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,746 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 302,209 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 858 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.