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Oncotarget

Article Metrics

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression

Overview of attention for article published in Oncotarget, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

Mentioned by

patent
1 patent

Citations

dimensions_citation
63 Dimensions

Readers on

mendeley
152 Mendeley
Title
Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression
Published in
Oncotarget, December 2014
DOI 10.18632/oncotarget.2953
Pubmed ID
Authors

Adrian P. Rybak, Robert G. Bristow, Anil Kapoor

Abstract

The cells of the prostate gland are dependent on cell signaling pathways to regulate their growth, maintenance and function. However, perturbations in key signaling pathways, resulting in neoplastic transformation of cells in the prostate epithelium, are likely to generate subtypes of prostate cancer which may subsequently require different treatment regimes. Accumulating evidence supports multiple sources of stem cells in the prostate epithelium with distinct cellular origins for prostate tumorigenesis documented in animal models, while human prostate cancer stem-like cells (PCSCs) are typically enriched by cell culture, surface marker expression and functional activity assays. As future therapies will require a deeper understanding of its cellular origins as well as the pathways that drive PCSC maintenance and tumorigenesis, we review the molecular and functional evidence supporting dysregulation of PI3K/AKT, RAS/MAPK and STAT3 signaling in PCSCs, the development of castration resistance, and as a novel treatment approach for individual men with prostate cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 152 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Germany 1 <1%
Italy 1 <1%
Unknown 149 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 37 24%
Student > Bachelor 24 16%
Student > Master 22 14%
Researcher 17 11%
Student > Doctoral Student 12 8%
Other 16 11%
Unknown 24 16%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 42 28%
Agricultural and Biological Sciences 34 22%
Medicine and Dentistry 26 17%
Pharmacology, Toxicology and Pharmaceutical Science 10 7%
Chemistry 3 2%
Other 10 7%
Unknown 27 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2019.
All research outputs
#5,609,698
of 17,366,233 outputs
Outputs from Oncotarget
#2,630
of 13,446 outputs
Outputs of similar age
#122,390
of 329,214 outputs
Outputs of similar age from Oncotarget
#262
of 1,585 outputs
Altmetric has tracked 17,366,233 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,446 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,214 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 1,585 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.