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Oncotarget

Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression

Overview of attention for article published in Oncotarget, December 2014
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (63rd percentile)

Mentioned by

patent
1 patent

Citations

dimensions_citation
81 Dimensions

Readers on

mendeley
192 Mendeley
Title
Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression
Published in
Oncotarget, December 2014
DOI 10.18632/oncotarget.2953
Pubmed ID
Authors

Adrian P. Rybak, Robert G. Bristow, Anil Kapoor

Abstract

The cells of the prostate gland are dependent on cell signaling pathways to regulate their growth, maintenance and function. However, perturbations in key signaling pathways, resulting in neoplastic transformation of cells in the prostate epithelium, are likely to generate subtypes of prostate cancer which may subsequently require different treatment regimes. Accumulating evidence supports multiple sources of stem cells in the prostate epithelium with distinct cellular origins for prostate tumorigenesis documented in animal models, while human prostate cancer stem-like cells (PCSCs) are typically enriched by cell culture, surface marker expression and functional activity assays. As future therapies will require a deeper understanding of its cellular origins as well as the pathways that drive PCSC maintenance and tumorigenesis, we review the molecular and functional evidence supporting dysregulation of PI3K/AKT, RAS/MAPK and STAT3 signaling in PCSCs, the development of castration resistance, and as a novel treatment approach for individual men with prostate cancer.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 192 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Italy 1 <1%
Germany 1 <1%
Unknown 189 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 21%
Student > Bachelor 30 16%
Student > Master 29 15%
Researcher 21 11%
Student > Doctoral Student 13 7%
Other 19 10%
Unknown 39 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 53 28%
Agricultural and Biological Sciences 35 18%
Medicine and Dentistry 32 17%
Pharmacology, Toxicology and Pharmaceutical Science 11 6%
Chemistry 4 2%
Other 16 8%
Unknown 41 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2019.
All research outputs
#7,541,115
of 23,006,268 outputs
Outputs from Oncotarget
#3,764
of 14,344 outputs
Outputs of similar age
#108,824
of 362,573 outputs
Outputs of similar age from Oncotarget
#87
of 314 outputs
Altmetric has tracked 23,006,268 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,344 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 362,573 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 314 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.