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Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1α/OATPs signaling axis

Overview of attention for article published in Oncotarget, October 2014
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Title
Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1α/OATPs signaling axis
Published in
Oncotarget, October 2014
DOI 10.18632/oncotarget.2464
Pubmed ID
Authors

Changhong Shi, Jason Boyang Wu, Gina C-Y. Chu, Qinlong Li, Ruoxiang Wang, Caiqin Zhang, Yi Zhang, Hyung L. Kim, Jing Wang, Haiyen E. Zhau, Dongfeng Pan, Leland W.K. Chung

Abstract

Near-infrared (NIR) fluorescence imaging agents are promising tools for noninvasive cancer imaging. This study explored the specific uptake and retention of a NIR heptamethine carbocyanine MHI-148 dye by canine cancer cells and tissues and human prostate cancer (PCa) specimens and also the dye uptake mechanisms. The accumulation of MHI-148 was detected specifically in canine cancer cells and tissues and freshly harvested human PCa tissues xenografted in mice by NIR fluorescence microscopy and whole-body NIR optical imaging. Specific dye uptake in canine spontaneous tumors was further confirmed by PET imaging. Higher hypoxia-inducible factor-1α (HIF-1α) and organic anion-transporting polypeptide (OATP) protein and mRNA expression was demonstrated by multiplex quantum dots labeling and qPCR in tumors over that of normal tissues. Treating cancer cells with HIF-1α stabilizers activated HIF-1α downstream target genes, induced OATP superfamily gene expression and enhanced cellular uptake and retention of NIR dyes. Moreover, silencing HIF-1α by siRNA significantly decreased OATP mRNA expression and blocked NIR dye uptake in cancer cells. Together, these results demonstrated the preferential uptake of NIR dyes by canine and human cancer cells and tissues via the HIF-1α/OATPs signaling axis, which provides insights into future application of these dyes for cancer detection and treatment.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Unknown 24 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 24%
Student > Ph. D. Student 4 16%
Researcher 3 12%
Student > Master 2 8%
Student > Doctoral Student 2 8%
Other 3 12%
Unknown 5 20%
Readers by discipline Count As %
Medicine and Dentistry 5 20%
Biochemistry, Genetics and Molecular Biology 4 16%
Chemistry 3 12%
Agricultural and Biological Sciences 2 8%
Veterinary Science and Veterinary Medicine 1 4%
Other 3 12%
Unknown 7 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 November 2014.
All research outputs
#13,280,442
of 15,033,985 outputs
Outputs from Oncotarget
#8,648
of 12,685 outputs
Outputs of similar age
#191,475
of 233,547 outputs
Outputs of similar age from Oncotarget
#122
of 208 outputs
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We're also able to compare this research output to 208 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.