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Osteoprotegerin rich tumor microenvironment: implications in breast cancer

Overview of attention for article published in Oncotarget, April 2016
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1 Facebook page

Citations

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30 Mendeley
Title
Osteoprotegerin rich tumor microenvironment: implications in breast cancer
Published in
Oncotarget, April 2016
DOI 10.18632/oncotarget.8658
Pubmed ID
Authors

Sudeshna Goswami, Neelam Sharma-Walia

Abstract

Osteoprotegerin (OPG) is a soluble decoy receptor for tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL). It belongs to the tumor necrosis factor receptor superfamily (TNFRSF). OPG was initially discovered to contribute to homeostasis of bone turnover due to its capability of binding to receptor activator of nuclear factor-kappaB (NF-kB). However, apart from bone turnover, OPG plays important and diverse role(s) in many biological functions. Besides having anti-osteoclastic activity, OPG is thought to exert a protective anti-apoptotic action in OPG-expressing tumors by overcoming the physiologic mechanism of tumor surveillance exerted by TRAIL. Along with inhibiting TRAIL induced apoptosis, it can induce proliferation by binding to various cell surface receptors and thus turning on the canonical cell survival and proliferative pathways. OPG also induces angiogenesis, one of the hallmarks of cancer, thus facilitating tumor growth. Recently, the understanding of OPG and its different roles has been augmented substantially. This review is aimed at providing a very informative overview as to how OPG affects cancer progression especially breast cancer.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 30%
Student > Master 5 17%
Student > Doctoral Student 4 13%
Student > Bachelor 3 10%
Professor 2 7%
Other 3 10%
Unknown 4 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 30%
Medicine and Dentistry 5 17%
Agricultural and Biological Sciences 5 17%
Immunology and Microbiology 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 10%
Other 0 0%
Unknown 5 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 March 2018.
All research outputs
#11,266,417
of 12,662,564 outputs
Outputs from Oncotarget
#7,966
of 11,845 outputs
Outputs of similar age
#236,597
of 271,884 outputs
Outputs of similar age from Oncotarget
#283
of 414 outputs
Altmetric has tracked 12,662,564 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,845 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,884 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 414 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.