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γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers

Overview of attention for article published in Oncotarget, November 2015
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1 tweeter

Citations

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23 Mendeley
Title
γKlotho is a novel marker and cell survival factor in a subset of triple negative breast cancers
Published in
Oncotarget, November 2015
DOI 10.18632/oncotarget.6006
Pubmed ID
Authors

Nuša Trošt, Samuel Peña-Llopis, Sajjan Koirala, Jurij Stojan, Patrick Ryan Potts, Klementina Fon Tacer, Elisabeth D. Martinez

Abstract

Over the last decade, breast cancer mortality has declined. However, triple negative breast cancer (TNBC) remains a challenging problem mostly due to early recurrence and lack of molecularly driven treatments. There is a critical need to identify subgroups of TNBC with common molecular features that can be therapeutically targeted. Here we show that in contrast to Klotho and βKlotho, the third member of the Klotho protein family, γKlotho, is overexpressed in more than 60% of TNBCs and correlates with poorer disease progression. Furthermore, we find that γKlotho is expressed in a subset of TNBC cell lines promoting cell growth. Importantly, we demonstrate that in these cells γKlotho is necessary for cell survival and that its depletion leads to constitutive ERK activation, cell cycle arrest and apoptosis. Interestingly, we observe increased oxidative stress in γKlotho-depleted cells suggesting that γKlotho enables cancer cells to cope with an oxidative environment and that cells become dependent on its expression to maintain this survival advantage. These findings indicate that γKlotho might be a potential marker for patients that would benefit from treatments that alter oxidative stress and constitutes a novel drug target for a subset of TN breast cancers.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 17%
Student > Bachelor 4 17%
Student > Doctoral Student 2 9%
Student > Master 2 9%
Other 2 9%
Other 3 13%
Unknown 6 26%
Readers by discipline Count As %
Medicine and Dentistry 8 35%
Biochemistry, Genetics and Molecular Biology 5 22%
Agricultural and Biological Sciences 3 13%
Engineering 1 4%
Unknown 6 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 November 2015.
All research outputs
#5,598,182
of 6,562,576 outputs
Outputs from Oncotarget
#3,688
of 6,087 outputs
Outputs of similar age
#166,748
of 209,310 outputs
Outputs of similar age from Oncotarget
#558
of 908 outputs
Altmetric has tracked 6,562,576 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,087 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 908 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.