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Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

Overview of attention for article published in Oncotarget, April 2015
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Title
Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts
Published in
Oncotarget, April 2015
DOI 10.18632/oncotarget.3960
Pubmed ID
Authors

Marco Trerotola, Kirat K. Ganguly, Ladan Fazli, Carmine Fedele, Huimin Lu, Anindita Dutta, Qin Liu, Tiziana De Angelis, Luke W. Riddell, Natalia A. Riobo, Martin E. Gleave, Amina Zoubeidi, Richard G. Pestell, Dario C. Altieri, Lucia R. Languino

Abstract

In this study, we show that the transmembrane glycoprotein Trop-2 is up-regulated in human prostate cancer (PCa) with extracapsular extension (stages pT3/pT4) as compared to organ-confined (stage pT2) PCa. Consistent with this evidence, Trop-2 expression is found to be increased in metastatic prostate tumors of Transgenic Adenocarcinoma of Mouse Prostate mice and to strongly correlate with α5β1 integrin levels. Using PCa cells, we show that Trop-2 specifically associates with the α5 integrin subunit, as binding to α3 is not observed, and that Trop-2 displaces focal adhesion kinase from focal contacts. In support of the role of Trop-2 as a promoter of PCa metastatic phenotype, we observe high expression of this molecule in exosomes purified from Trop-2-positive PCa cells. These vesicles are then found to promote migration of Trop-2-negative PCa cells on fibronectin, an α5β1 integrin/focal adhesion kinase substrate, thus suggesting that the biological function of Trop-2 may be propagated to recipient cells. In summary, our findings show that Trop-2 promotes an α5β1 integrin-dependent pro-metastatic signaling pathway in PCa cells and that the altered expression of Trop-2 may be utilized for early identification of capsule-invading PCa.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 51 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 32%
Researcher 8 15%
Student > Bachelor 6 11%
Other 4 8%
Student > Master 4 8%
Other 5 9%
Unknown 9 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 26%
Agricultural and Biological Sciences 12 23%
Medicine and Dentistry 12 23%
Chemistry 2 4%
Computer Science 1 2%
Other 1 2%
Unknown 11 21%