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Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Overview of attention for article published in Oncotarget, November 2014
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Title
Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity
Published in
Oncotarget, November 2014
DOI 10.18632/oncotarget.2820
Pubmed ID
Authors

Itsuhiro Takizawa, Mitchell G. Lawrence, Preetika Balanathan, Richard Rebello, Helen B. Pearson, Elika Garg, John Pedersen, Normand Pouliot, Robert Nadon, Matthew J. Watt, Renea A. Taylor, Patrick Humbert, Ivan Topisirovic, Ola Larsson, Gail P. Risbridger, Luc Furic

Abstract

While high doses of estrogen, in combination with androgens, can initiate prostate cancer (PCa) via activation of the estrogen receptor α (ERα), the role of ERα in PCa cells within established tumors is largely unknown. Here we show that expression of ERα is increased in high grade human PCa. Similarly, ERα is elevated in mouse models of aggressive PCa driven by MYC overexpression or deletion of PTEN. Within the prostate of PTEN-deficient mice, there is a progressive pattern of ERα expression: low in benign glands, moderate in tumors within the dorsal, lateral and ventral lobes, and high in tumors within the anterior prostate. This expression significantly correlates with the proliferation marker Ki67. Furthermore, in vitro knockdown of ERα in cells derived from PTEN-deficient tumors causes a significant and sustained decrease in proliferation. Depletion of ERα also reduces the activity of the PI3K and MAPK pathways, both downstream targets of non-genomic ERα action. Finally, ERα knockdown reduces the levels of the MYC protein and lowers the sensitivity of cellular proliferation to glucose withdrawal, which correlates with decreased expression of the glucose transporter GLUT1. Collectively, these results demonstrate that ERα orchestrates proliferation and metabolism to promote the neoplastic growth of PCa cells.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Bachelor 6 16%
Student > Doctoral Student 4 11%
Student > Postgraduate 3 8%
Other 3 8%
Other 9 24%
Unknown 3 8%
Readers by discipline Count As %
Medicine and Dentistry 13 35%
Biochemistry, Genetics and Molecular Biology 9 24%
Agricultural and Biological Sciences 8 22%
Immunology and Microbiology 1 3%
Neuroscience 1 3%
Other 0 0%
Unknown 5 14%