Title |
Exosomes in diagnosis and therapy of prostate cancer
|
---|---|
Published in |
Oncotarget, June 2017
|
DOI | 10.18632/oncotarget.18532 |
Pubmed ID | |
Authors |
Jun Pan, Meng Ding, Kai Xu, Chunhua Yang, Li-Jun Mao |
Abstract |
Exosomes are small vesicular bodies released by a variety of cells. Exosomes contain miRNAs, mRNAs and proteins with the potential to regulate signaling pathways in recipient cells. Exosomes deliver nucleic acids and proteins to mediate the communication between cancer cells and stroma cells. In this review, we summarize recent progress in our understanding of the role of exosomes in prostate cancer. The tumorigenesis, metastasis and drug resistance of prostate cancer are associated with the cargos of exosomes such as miRNAs, lncRNAs and proteins. In addition, prostate cancer cells modulate surrounding stromal cells via the exosomes. Affected stromal cells employ the exosomes to modulate microenvironment and promote tumor growth and metastasis. Exosomes derived from prostate cancer cells contribute to cancer chemoresistance. The lipid bilayer membrane of the exosomes makes them promising carriers of drugs and other therapeutic molecules targeting prostate cancer. Furthermore, exosomes can be detected and isolated from various body fluids for the diagnosis of prostate cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 33% |
United Kingdom | 1 | 11% |
Colombia | 1 | 11% |
Unknown | 4 | 44% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 78% |
Science communicators (journalists, bloggers, editors) | 2 | 22% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 107 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 21% |
Student > Bachelor | 18 | 17% |
Researcher | 12 | 11% |
Student > Doctoral Student | 7 | 7% |
Student > Master | 7 | 7% |
Other | 11 | 10% |
Unknown | 30 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 30 | 28% |
Medicine and Dentistry | 16 | 15% |
Agricultural and Biological Sciences | 10 | 9% |
Chemistry | 4 | 4% |
Immunology and Microbiology | 2 | 2% |
Other | 9 | 8% |
Unknown | 36 | 34% |