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Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

Overview of attention for article published in Oncotarget, November 2014
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  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

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2 X users

Citations

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226 Dimensions

Readers on

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281 Mendeley
Title
Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts
Published in
Oncotarget, November 2014
DOI 10.18632/oncotarget.2711
Pubmed ID
Authors

Ridwana Chowdhury, Jason P. Webber, Mark Gurney, Malcolm D. Mason, Zsuzsanna Tabi, Aled Clayton

Abstract

Stromal fibroblasts become altered in response to solid cancers, to exhibit myofibroblastic characteristics, with disease promoting influence. Infiltrating mesenchymal stem cells (MSC) may contribute towards these changes, but the factors secreted by cancer cells that impact MSC differentiation are poorly understood. We investigated the role of nano-metre sized vesicles (exosomes), secreted by prostate cancer cells, on the differentiation of bone-marrow MSC (BM-MSC), and the subsequent functional consequences of such changes. Purified exosomes impaired classical adipogenic differentiation, skewing differentiation towards alpha-smooth muscle actin (αSMA) positive myofibroblastic cells. A single exosomes treatment generated myofibroblasts secreting high levels of VEGF-A, HGF and matrix regulating factors (MMP-1, -3 and -13). Differentiated MSC had pro-angiogenic functions and enhanced tumour proliferation and invasivity assessed in a 3D co-culture model. Differentiation was dependent on exosomal-TGFβ, but soluble TGFβ at matched dose could not generate the same phenotype. Exosomes present in the cancer cell secretome were the principal factors driving this phenotype. Prostate cancer exosomes dominantly dictate a programme of MSC differentiation generating myofibroblasts with functional properties consistent with disease promotion.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 281 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 <1%
Chile 1 <1%
Portugal 1 <1%
United States 1 <1%
Unknown 276 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 72 26%
Researcher 42 15%
Student > Master 39 14%
Student > Bachelor 35 12%
Student > Doctoral Student 11 4%
Other 31 11%
Unknown 51 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 67 24%
Agricultural and Biological Sciences 57 20%
Medicine and Dentistry 45 16%
Pharmacology, Toxicology and Pharmaceutical Science 11 4%
Engineering 8 3%
Other 24 9%
Unknown 69 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2015.
All research outputs
#14,794,387
of 22,778,347 outputs
Outputs from Oncotarget
#6,009
of 14,321 outputs
Outputs of similar age
#203,489
of 361,912 outputs
Outputs of similar age from Oncotarget
#124
of 293 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,321 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.5. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,912 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 293 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.