↓ Skip to main content

Oncotarget

Article Metrics

LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer

Overview of attention for article published in Oncotarget, September 2016
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • High Attention Score compared to outputs of the same age and source (95th percentile)

Mentioned by

twitter
14 tweeters
facebook
1 Facebook page
googleplus
2 Google+ users

Citations

dimensions_citation
28 Dimensions

Readers on

mendeley
41 Mendeley
Title
LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer
Published in
Oncotarget, September 2016
DOI 10.18632/oncotarget.11962
Pubmed ID
Authors

Whitney S. Henry, David G. Hendrickson, Francisco Beca, Benjamin Glass, Marianne Lindahl-Allen, Lizhi He, Zhe Ji, Kevin Struhl, Andrew H. Beck, John L. Rinn, Alex Toker

Abstract

Long non-coding RNAs (lncRNAs) have been implicated in normal cellular homeostasis as well as pathophysiological conditions, including cancer. Here we performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development. Specifically, our analysis revealed a novel lncRNA, LINC00520 that is upregulated upon ectopic expression of oncogenic v-Src, in a manner that is dependent on the transcription factor STAT3. Similarly, LINC00520 is also increased in mammary epithelial cells transformed by oncogenic PI3K and its expression is decreased upon knockdown of mutant PIK3CA. Additional expression profiling highlight that LINC00520 is elevated in a subset of human breast carcinomas, with preferential enrichment in the basal-like molecular subtype. ShRNA-mediated depletion of LINC00520 results in decreased cell migration and loss of invasive structures in 3D. RNA sequencing analysis uncovers several genes that are differentially expressed upon ectopic expression of LINC00520, a significant subset of which are also induced in v-Src-transformed MCF10A cells. Together, these findings characterize LINC00520 as a lncRNA that is regulated by oncogenic Src, PIK3CA and STAT3, and which may contribute to the molecular etiology of breast cancer.

Twitter Demographics

The data shown below were collected from the profiles of 14 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 22%
Student > Bachelor 8 20%
Student > Ph. D. Student 6 15%
Professor 4 10%
Researcher 4 10%
Other 4 10%
Unknown 6 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 16 39%
Medicine and Dentistry 7 17%
Agricultural and Biological Sciences 7 17%
Neuroscience 1 2%
Computer Science 1 2%
Other 2 5%
Unknown 7 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2019.
All research outputs
#2,119,229
of 16,510,444 outputs
Outputs from Oncotarget
#759
of 12,977 outputs
Outputs of similar age
#45,419
of 268,410 outputs
Outputs of similar age from Oncotarget
#46
of 1,079 outputs
Altmetric has tracked 16,510,444 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,977 research outputs from this source. They receive a mean Attention Score of 4.2. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,410 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 1,079 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.