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The histone demethylaseKDM3Aregulates the transcriptional program of the androgen receptor in prostate cancer cells

Overview of attention for article published in Oncotarget, March 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
14 news outlets
blogs
5 blogs
twitter
32 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
51 Dimensions

Readers on

mendeley
53 Mendeley
Title
The histone demethylaseKDM3Aregulates the transcriptional program of the androgen receptor in prostate cancer cells
Published in
Oncotarget, March 2017
DOI 10.18632/oncotarget.15681
Pubmed ID
Authors

Stephen Wilson, Lingling Fan, Natasha Sahgal, Jianfei Qi, Fabian V. Filipp

Abstract

The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity, and tumor progression. We matched transcriptomic and ChIP-Seq profiles to decipher a genome-wide regulatory network of epigenetic control by KDM3A in prostate cancer cells. ChIP-Seq experiments monitoring histone 3 lysine 9 (H3K9) methylation marks show global histone demethylation effects of KDM3A. Combined assessment of histone demethylation events and gene expression changes presented major transcriptional activation suggesting that distinct oncogenic regulators may synergize with the epigenetic patterns by KDM3A. Pathway enrichment analysis of cells with KDM3A knockdown prioritized androgen signaling indicating that KDM3A plays a key role in regulating androgen receptor activity. Matched ChIP-Seq and knockdown experiments of KDM3A in combination with ChIP-Seq of the androgen receptor resulted in a gain of H3K9 methylation marks around androgen receptor binding sites of selected transcriptional targets in androgen signaling including positive regulation of KRT19, NKX3-1, KLK3, NDRG1, MAF, CREB3L4, MYC, INPP4B, PTK2B, MAPK1, MAP2K1, IGF1, E2F1, HSP90AA1, HIF1A, and ACSL3. The cancer systems biology analysis of KDM3A-dependent genes identifies an epigenetic and transcriptional network in androgen response, hypoxia, glycolysis, and lipid metabolism. Genome-wide ChIP-Seq data highlights specific gene targets and the ability of epigenetic master regulators to control oncogenic pathways and cancer progression.

Twitter Demographics

The data shown below were collected from the profiles of 32 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 53 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 53 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 11 21%
Student > Ph. D. Student 9 17%
Researcher 8 15%
Other 4 8%
Student > Bachelor 4 8%
Other 8 15%
Unknown 9 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 15 28%
Agricultural and Biological Sciences 9 17%
Medicine and Dentistry 8 15%
Neuroscience 2 4%
Computer Science 1 2%
Other 5 9%
Unknown 13 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 162. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2021.
All research outputs
#151,242
of 18,671,420 outputs
Outputs from Oncotarget
#52
of 13,646 outputs
Outputs of similar age
#4,479
of 269,795 outputs
Outputs of similar age from Oncotarget
#4
of 836 outputs
Altmetric has tracked 18,671,420 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,646 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,795 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 836 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.