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Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer

Overview of attention for article published in Oncotarget, August 2017
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#12 of 13,644)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
54 news outlets
twitter
6 tweeters
facebook
1 Facebook page

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
17 Mendeley
Title
Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer
Published in
Oncotarget, August 2017
DOI 10.18632/oncotarget.20097
Pubmed ID
Authors

Shyam Kumar Gudey, Reshma Sundar, Carl-Henrik Heldin, Anders Bergh, Marene Landström

Abstract

Transforming growth factor β (TGFβ) is a key regulator of epithelial-to-mesenchymal transition (EMT) during embryogenesis and in tumors. The effect of TGFβ, on ΕΜΤ, is conveyed by induction of the pro-invasive transcription factor Snail1. In this study, we report that TGFβ stimulates Snail1 sumoylation in aggressive prostate, breast and lung cancer cells. Sumoylation of Snail1 lysine residue 234 confers its transcriptional activity, inducing the expression of classical EMT genes, as well as TGFβ receptor I (TβRI) and the transcriptional repressor Hes1. Mutation of Snail1 lysine residue 234 to arginine (K234R) abolished sumoylation of Snail1, as well as its migratory and invasive properties in human prostate cancer cells. An increased immunohistochemical expression of Snail1, Sumo1, TβRI, Hes1, and c-Jun was observed in aggressive prostate cancer tissues, consistent with their functional roles in tumorigenesis.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 24%
Professor 3 18%
Researcher 3 18%
Student > Ph. D. Student 2 12%
Student > Master 1 6%
Other 1 6%
Unknown 3 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 41%
Agricultural and Biological Sciences 5 29%
Immunology and Microbiology 1 6%
Neuroscience 1 6%
Unknown 3 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 432. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2019.
All research outputs
#38,195
of 18,646,156 outputs
Outputs from Oncotarget
#12
of 13,644 outputs
Outputs of similar age
#1,187
of 282,020 outputs
Outputs of similar age from Oncotarget
#3
of 1,551 outputs
Altmetric has tracked 18,646,156 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,644 research outputs from this source. They receive a mean Attention Score of 4.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,020 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,551 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.