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Intralesional rose bengal in melanoma elicits tumor immunityviaactivation of dendritic cells by the release of high mobility group box 1

Overview of attention for article published in Oncotarget, May 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#40 of 14,292)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

news
34 news outlets
twitter
6 tweeters
patent
6 patents
facebook
1 Facebook page

Citations

dimensions_citation
40 Dimensions

Readers on

mendeley
24 Mendeley
Title
Intralesional rose bengal in melanoma elicits tumor immunityviaactivation of dendritic cells by the release of high mobility group box 1
Published in
Oncotarget, May 2016
DOI 10.18632/oncotarget.9247
Pubmed ID
Authors

Hao Liu, Pasquale Patrick Innamarato, Krithika Kodumudi, Amy Weber, Satoshi Nemoto, John L. Robinson, Georgina Crago, Timothy McCardle, Erica Royster, Amod A. Sarnaik, Shari Pilon-Thomas

Abstract

Intralesional (IL) therapy is under investigation to treat dermal and subcutaneous metastatic cancer. Rose Bengal (RB) is a staining agent that was originally used by ophthalmologists and in liver function studies. IL injection of RB has been shown to induce regression of injected and uninjected tumors in murine models and clinical trials. In this study, we have shown a mechanism of tumor-specific immune response induced by IL RB. In melanoma-bearing mice, IL RB induced regression of injected tumor and inhibited the growth of bystander lesions mediated by CD8+ T cells. IL RB resulted in necrosis of tumor cells and the release of High Mobility Group Box 1 (HMGB1), with increased dendritic cell (DC) infiltration into draining lymph nodes and the activation of tumor-specific T cells. Treatment of DC with tumor supernatants increased the ability of DCs to stimulate T cell proliferation, and blockade of HMGB1 in the supernatants suppressed DC activity. Additionally, increased HMGB1 levels were measured in the sera of melanoma patients treated with IL RB. These results support the role of IL RB to activate dendritic cells at the site of tumor necrosis for the induction of a systemic anti-tumor immune response.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 13%
Student > Ph. D. Student 3 13%
Student > Master 3 13%
Student > Doctoral Student 2 8%
Professor 2 8%
Other 4 17%
Unknown 7 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 17%
Medicine and Dentistry 4 17%
Agricultural and Biological Sciences 2 8%
Chemistry 2 8%
Immunology and Microbiology 1 4%
Other 3 13%
Unknown 8 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 243. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2022.
All research outputs
#123,463
of 22,562,129 outputs
Outputs from Oncotarget
#40
of 14,292 outputs
Outputs of similar age
#2,523
of 281,452 outputs
Outputs of similar age from Oncotarget
#1
of 1,218 outputs
Altmetric has tracked 22,562,129 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 14,292 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,452 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,218 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.